O-Phospho-L-serine
Chemical Name: L-Serine-O-phosphate
Biological Activity
O-Phospho-L-serine is a group III metabotropic glutamate receptor agonist; analog of L-AP4 (Cat. No. 0103). Neuroprotective against excitotoxicity in cortical cell cultures. Inhibits proliferation and enhances neuronal differentiation in progenitor cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A chemical biology route to site-specific authentic protein modifications.
Yang et al.
Science, 2016;354:623 -
Expanding the genetic code of Escherichia coli with phosphoserine.
Park et al.
Science, 2011;333:1151 -
A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation.
Saxe et al.
Chem.Biol., 2007;14:1019 -
Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures.
Bruno et al.
Eur.J.Pharmacol., 1996;310:61 -
[3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a.
Eriksen and Thomsen
Br.J.Pharmacol., 1995;116:3279 -
Pharmacology of selective and non-selective metabotropic glutamate receptor agonists at L-AP4 receptors in ON bipolar cells.
Thoreson and Ulphani
Brain Res., 1995;676:93
Product Datasheets
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Citations for O-Phospho-L-serine
The citations listed below are publications that use Tocris products. Selected citations for O-Phospho-L-serine include:
2 Citations: Showing 1 - 2
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Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism.
Authors: Jiang Et al.
J Neurosci 2006;26:4318
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Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP.
Authors: Mathiesen Et al.
Br J Pharmacol 2003;138:1026
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