Recombinant Human TL1A/TNFSF15 Protein Summary
Product Specifications
Leu72-Leu251, with an N-terminal Met
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
1319-TL
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. |
| Reconstitution | Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
1319-TL/CF
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution | Reconstitute at 100 μg/mL in sterile PBS. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Reconstitution Calculator
Background: TL1A/TNFSF15
TL1A is a type II transmembrane protein belonging to the TNF superfamily and has been designated TNF superfamily member 15 (TNFSF15). Human TL1A is a 251 aa protein consisting of a 35 aa cytoplasmic domain, a 24 aa transmembrane region and a 192 aa C-terminal extracellular domain. It is a longer variant of the previously cloned TL1 (also known as VEGI) that is possibly a cloning artifact. TL1A is predominantly expressed in endothelial cells and its expression is inducible by TNF-alpha and IL-1 alpha. TL1A binds with high affinity to death receptor 3 (DR3), which is now designated TNF receptor superfamily member 25 (TNFRSF25). DR3 was formerly designated TNFRSF12 when it was thought to be the receptor for TWEAK/TNFSF12. DR3 is expressed primarily on activated T cells. Depending on the cell context, ligation of DR3 by TL1A can trigger one of two signaling pathways, activation of the transcription factor NF-kappa-B or activation of caspases and apoptosis. On primary T cells, TL1A induces NF-kappa-B activation and a costimulatory signal to increase IL-2 responsiveness and the secretion of proinflammatory cytokines. However, in a tumor cell line, TF-1, TL1A has been shown to induce caspase activity and apoptosis. These effects of TL1A are blocked by the secreted, soluble decoy receptor 3 (DcR3), also known as TR6 and TNFRSF6B, which compete with DR3 for binding to TL1A. Consistent with the observed in vitro activities, TL1A promotes ex vivo splenocyte expansion and enhances in vivo graft-versus-host-response.
Citations for Recombinant Human TL1A/TNFSF15 Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells
Authors: J Fritsch, J Frankenhei, L Marischen, T Vadasz, A Troeger, S Rose-John, D Schmidt-Ar, W Schneider-
Cells, 2021-11-10;10(11):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TL1A-DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1-Specific T Cell Responses
Authors: B Oriol-Tord, A Olvera, C Duran-Cast, A Llano, B Mothe, M Massanella, J Dalmau, C Ganoza, J Sanchez, ML Calle, B Clotet, J Martinez-P, E Negredo, J Blanco, D Hartigan-O, C Brander, M Ruiz-Riol
J Immunol, 2020-11-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG
Authors: K Landgraf, N Klöting, M Gericke, N Maixner, E Guiu-Jurad, M Scholz, AV Witte, F Beyer, JT Schwartze, M Lacher, A Villringer, P Kovacs, A Rudich, M Blüher, W Kiess, A Körner
Cell Rep, 2020-10-20;33(3):108295.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The TL1A-DR3 Axis Selectively Drives Effector Functions in Human MAIT Cells
Authors: A Sattler, LG Thiel, AH Ruhm, N Souidi, M Seifert, G Herberth, K Kotsch
J. Immunol., 2019-10-18;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions
Authors: T Leng, HD Akther, CP Hackstein, K Powell, T King, M Friedrich, Z Christofor, S McCuaig, M Neyazi, CV Arancibia-, J Hagel, F Powrie, RS Peres, V Millar, D Ebner, R Lamichhane, J Ussher, TSC Hinks, E Marchi, C Willberg, P Klenerman
Cell Rep, 2019-09-17;28(12):3077-3091.e5.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Directed evolution of a soluble human DR3 receptor for the inhibition of TL1A induced cytokine secretion
Authors: I Levin, M Zaretsky, A Aharoni
PLoS ONE, 2017-03-09;12(3):e0173460.
Species: Human, Yeast
Sample Types: Whole Cells
Applications: Bioassay, Flow Cytometry -
PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells
Sci Rep, 2016-11-09;6(0):36795.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CX(3)CR1(+) mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.
Authors: Longman R, Diehl G, Victorio D, Huh J, Galan C, Miraldi E, Swaminath A, Bonneau R, Scherl E, Littman D
J Exp Med, 2014-07-14;211(8):1571-83.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TL1A increased the differentiation of peripheral Th17 in rheumatoid arthritis.
Authors: Zhou M, Liu R, Su D, Feng X, Li X
Cytokine, 2014-05-13;69(1):125-30.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Progranulin-derived Atsttrin directly binds to TNFRSF25 (DR3) and inhibits TNF-like ligand 1A (TL1A) activity.
Authors: Liu, Cui, Li, Xing-Xia, Gao, Wei, Liu, Wen, Liu, De-Shan
PLoS ONE, 2014-03-20;9(3):e92743.
Species: Human, Mouse
Sample Types: Protein, Whole Cells
Applications: Binding Assay, Bioassay -
TL1A induces TCR independent IL-6 and TNF-alpha production and growth of PLZF(+) leukocytes.
Authors: Reichwald K, Jorgensen T, Tougaard P, Skov S
PLoS ONE, 2014-01-08;9(1):e85793.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
Nature, 2012-07-26;487(7408):505-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The endothelial cell-produced antiangiogenic cytokine vascular endothelial growth inhibitor induces dendritic cell maturation.
Authors: Tian F, Grimaldo S, Fujita M, Fugita M, Cutts J, Vujanovic NL, Li LY
J. Immunol., 2007-09-15;179(6):3742-51.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay
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Average Rating: 5 (Based on 2 Reviews)
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Reason for Rating: Recombinant human TL1A is bound by patented anti-TL1a antibodies via direct ELISA.
