BPIPP
Chemical Name: 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione
Purity: ≥99%
Biological Activity
Non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. Downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM). Inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: application for treatment of diarrhea.
Kots et al.
Proc.Natl.Acad.Sci.USA, 2008;105:8440 -
Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons
N Nakashima, K Nakashima, A Taura, A Takaku-Nak, H Ohmori, M Takano
Nat Commun, 2020;11(1):2188.
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