Recombinant Human TGF-beta 1.2 Protein
Recombinant Human TGF-beta 1.2 Protein Summary
Product Specifications
| Human TGF-beta 1 (Ala279-Ser390) Accession # P01137 |
| Human TGF-beta 2 (Ala303-Ser414) Accession # P61812 |
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| N-terminus | C-terminus | |
Analysis
Product Datasheets
304-B3/CF (carrier free)
Discontinued Product
304-B3
| Formulation | Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein. |
| Reconstitution | Reconstitute at 10 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Background: TGF-beta 1.2
Transforming Growth Factor Beta (TGF-beta ) is a stable, multifunctional polypeptide growth factor. While specific receptors for this protein have been found on almost all mammalian cell types thus far examined, the effect of the molecule varies depending on the cell type and growth conditions. Generally, TGF-beta is stimulatory for cells of mesenchymal origin and inhibitory for cells of epithelial or neuroectodermal origin. It is now known that the originally described form of TGF-beta, now described as TGF-beta 1, is only one of a family of regulatory proteins consisting of a number of proteins distantly related to TGF-beta 1 (30 - 40% sequence homology) and a number of more closely related proteins (70 - 80% sequence homology) designated TGF-beta 2, TGF-beta 1.2, TGF-beta 3, TGF-beta 4, and TGF-beta 5. TGF-beta 1 has been found in the highest concentration in human platelets and mammalian bone, but is produced by many cell types in smaller amounts. TGF-beta 2 has been found in the highest concentration in porcine platelets and mammalian bone, but again is also produced by many types of cells. The heterodimer, TGF-beta 1.2, has so far been found only in small amounts in porcine platelets. TGF-beta 3 has been detected in human, porcine, and avian sources, mainly in cells of mesenchymal origin, suggesting a different role for this protein than for TGF-beta 1 or -beta 2. TGF-beta 4 has been detected in chick embryo chondrocytes, and its distribution in other types of cells is being investigated. TGF-beta 5 has been detected only in Xenopus embryos. TGF-beta 1, TGF-beta 2, and TGF-beta 1.2 appear to be largely equivalent in biological activity, although there appear to be differences in binding to certain types of receptors, and there are a few reports of differential responses to TGF-beta 1 and TGF-beta 2.
Citation for Recombinant Human TGF-beta 1.2 Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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Cutting edge: immune cells as sources and targets of the IL-10 family members?
Authors: Wolk K, Kunz S, Asadullah K, Sabat R
J. Immunol., 2002-06-01;168(11):5397-402.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay
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