Home / Indoleamine 2,3 Dioxygenase Inhibitors / 1-Methyl-D-tryptophan

1-Methyl-D-tryptophan

Catalog #: 5698
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5698/50
1-Methyl-D-tryptophan | CAS No. 110117-83-4 | Indoleamine 2,3 Dioxygenase Inhibitors
1 Image
Description: Indoleamine 2,3-dioxygenase (IDO) inhibitor
Alternative Names: 1MT

Purity: ≥97%

Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

1-Methyl-D-tryptophan is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO.

Technical Data

M.Wt:
218.25
Formula:
C12H14N2O2
Solubility:
Soluble to 5 mM in water with gentle warming
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
110117-83-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice.
    Nakamura et al.
    Int.J.Hematol., 2015;102:327
  2. Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase.
    Rytelewski, Mateusz, Meilleur, Courtney, Yekta, Maryam A, Szabo, Peter A, Garg, Nitan, Schell, Todd D, Jevnikar, Anthony, Sharif, Shayan, Singh, Bhagirat, Haeryfar, S M Mans
    PLoS ONE, 2014-02-28;9(2):e90439.

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for 1-Methyl-D-tryptophan

The citations listed below are publications that use Tocris products. Selected citations for 1-Methyl-D-tryptophan include:

1 Citation: Showing 1 - 1

  1. Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39.
    Authors: Howard L Et al.
    Nat Neurosci  2019;22:729-740

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for 1-Methyl-D-tryptophan

There are currently no reviews for this product. Be the first to review 1-Methyl-D-tryptophan and earn rewards!

Have you used 1-Methyl-D-tryptophan?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.