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142D6

Catalog #: 8018 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8018/5
142D6 | CAS No. 2410953-19-2 | IAP Inhibitors
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Description: Potent Lys-covalent pan-IAP inhibitor

Chemical Name: (R)-1-((S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamido)-2,3-dihydro-1H-inden-4-yl sulfurofluoridate

Purity: ≥95%

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Biological Activity

142D6 is a potent pan-IAP inhibitor (IC50 values are 21, 21 and 43 nM for cIAP1, cIAP2 and XIAP respectively). 142D6 covalently targets Lys residues in the BIR3 domain of the inhibitor of the apoptosis protein (IAP) family. In vitro, 142D6 reduces viability of cultured breast cancer MDA-MB-231 cells (EC50 values are 44 and 61 nM in cell viability and apoptosis assays, respectively). 142D6 is chemically stable in buffer and plasma and is orally bioavailable.

Technical Data

M.Wt:
552.66
Formula:
C26H37FN4O6S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2410953-19-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under patent license from The Regents of the University of California

Product Datasheets

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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