4-Thiouridine
Chemical Name: 4-Thiouridine
Purity: ≥98%
Biological Activity
4-Thiouridine is a photoreactive uridine analog for RNA sequencing (RNA seq) and thiol(SH)-linked alkylation for the metabolic sequencing of RNA (SLAM seq). Used as a crosslinker to identify RNA binding proteins. Is incorporated into newly transcribed RNA and can be used to track RNA from synthesis to degradation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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TimeLapse-seq: adding a temporal dimension to RNA sequencing through nucleoside recoding.
Schofield et al.
Nat.Methods, 2018;15:221 -
Isolation of newly transcribed RNA using the metabolic label 4-thiouridine.
Garibaldi et al.
Methods Mol.Biol., 2017;1648:169 -
Thiol-linked alkylation of RNA to assess expression dynamics.
Herzog et al.
Nat.Methods, 2017;14:1198
Product Datasheets
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Citations for 4-Thiouridine
The citations listed below are publications that use Tocris products. Selected citations for 4-Thiouridine include:
2 Citations: Showing 1 - 2
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In vivo PAR-CLIP (viP-CLIP) of liver TIAL1 unveils targets regulating cholesterol synthesis and secretion.
Authors: Cindy Et al.
Nat Commun 2023;14:3386
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Genetic Deletion of Polo-Like Kinase 2 Induces a Pro-Fibrotic Pulmonary Phenotype.
Authors: Ali Et al.
Cells 2021;10
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