4EGI-1

Catalog #: 4800
5 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
4800/10
4800/50

4EGI-1 | CAS No. 315706-13-9 | Protein-synthesizing GTPase Compounds

1 Image

Description: Inhibits eIF4E:eIF4G subunit interaction

Chemical Name: α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid

Purity: ≥98%

View All Products for Protein-synthesizing GTPase Compounds

Product Details

Citations (5)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

4EGI-1 is an inhibitor of eIF4E:eIF4G interaction; prevents eIF4E binding to eIF4G. Binds eIF4E and inhibits cap-dependent translation but not initiation factor-independent translation. Exhibits activity against Jurkat and A549 cells.

Technical Data

M.Wt:

451.28

Formula:

C₁₈H₁₂Cl₂N₄O₄S

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

315706-13-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Autism-related deficits via dysregulated eIF4E-dependent translational control.
Gkogkas C, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill D, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille J, Sonenberg N
Nature, 2013;493(7432):371-7.
Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G.
Moerke et al.
Cell, 2007;128:257

Product Datasheets

COA view current batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for 4EGI-1

The citations listed below are publications that use Tocris products. Selected citations for 4EGI-1 include:

5 Citations: Showing 1 - 5

High-throughput translational profiling with riboPLATE-seq.
Authors: Christian Et al.
Sci Rep 2022;12:5718
CUL3 Deficiency Causes Social Deficits and Anxiety-like Behaviors by Impairing Excitation-Inhibition Balance through the Promotion of Cap-Dependent Translation.
Authors: Lei Et al.
Neuron 2020;105:475-490.e6
The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling.
Authors: Rolf Et al.
Cell Metab 2018;28:895-906.e5
Autophagy is a signature of a signaling network that maintains hematopoietic stem cells.
Authors: Michelle Et al.
PLoS One 2017;12:e0177054
Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming.
Authors: Riz Et al.
Oncotarget 2016;7:66360

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for 4EGI-1

There are currently no reviews for this product. Be the first to review 4EGI-1 and earn rewards!

Have you used 4EGI-1?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.