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5,7-Dichlorokynurenic acid

Catalog #: 0286
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0286/10
0286/50
5,7-Dichlorokynurenic acid | CAS No. 131123-76-7 | NMDA Receptor Antagonists
1 Image
Description: Potent NMDA antagonist; acts at glycine site

Chemical Name: 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid

Purity: ≥98%

Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

5,7-Dichlorokynurenic acid is a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine).

Sodium Salt also available.

Technical Data

M.Wt:
258.06
Formula:
C10H5Cl2NO3
Solubility:
Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
131123-76-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site.
    Baron et al.
    Mol.Pharmacol., 1990;38:554
  3. Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor.
    Moore et al.
    Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I, 1990;

Product Datasheets

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Citations for 5,7-Dichlorokynurenic acid

The citations listed below are publications that use Tocris products. Selected citations for 5,7-Dichlorokynurenic acid include:

4 Citations: Showing 1 - 4

  1. Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement.
    Authors: Adamsky Et al.
    Cell  2018;174:59
  2. An excitatory GABA loop operating in vivo.
    Authors: Astorga Et al.
    Front Cell Neurosci  2015;9:275
  3. Light-evoked NMDA receptor-mediated currents are reduced by blocking D-serine synthesis in the salamander retina.
    Authors: Stevens Et al.
    Cell Commun Signal  2010;21:239
  4. The integrity of the glycine co-agonist binding site of N-MthD.-aspartate receptors is a functional quality control checkpoint for cell surface delivery.
    Authors: Kenny Et al.
    J Biol Chem  2009;284:324

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