7-Chlorokynurenic acid sodium salt
Chemical Name: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
Purity: ≥98%
Biological Activity
7-Chlorokynurenic acid sodium salt is a sodium salt of 7-Chlorokynurenic acid (Cat.No. 0237), an NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats.
Kretschmer et al.
Eur.J.Pharmacol., 1995;280:37 -
Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles.
Bartlett et al.
Neuropharmacology, 1998;37:839 -
7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex.
Kemp et al.
Proc.Natl.Acad.Sci.USA, 1988;85:6547 -
Characterization of the [3H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain.
Donald et al.
Br.J.Pharmacol., 1988;95:892P
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Citations for 7-Chlorokynurenic acid sodium salt
The citations listed below are publications that use Tocris products. Selected citations for 7-Chlorokynurenic acid sodium salt include:
2 Citations: Showing 1 - 2
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PSD-95 protects synapses from β-amyloid.
Authors: Roberto Et al.
Cell Rep 2021;35:109194
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Projection-dependent heterogeneity of cerebellar granule cell calcium responses.
Authors: Jun Kyu Et al.
Mol Brain 2021;14:63
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We used this drug in bath application to block ion flow through NMDA receptors and observe dendritic spine structural plasticity int he absence of ion flow.
We incubate with this drug for at least 30 minutes before use. We are using cultured hippocampus slices.
