7-Chlorokynurenic acid

Biological Activity

Sodium Salt also available.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Contribution of astroglial Cx43 hemichannels to the modulation of glutamatergic currents by D-serine in the mouse prefrontal cortex
   C Meunier, N Wang, C Yi, G Dallerac, P Ezan, A Koulakoff, L Leybaert, C Giaume
   J. Neurosci., 2017;0(0):.
2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
3. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
   Tollefson and Taylor
   CNS Drug Reviews, 2000;6:303
4. Behavioral and neurochemical actions of the strychnine-insensitive glycine receptor antagonist, 7-chlorokynurenate, in rats.
   Kretschmer et al.
   Eur.J.Pharmacol., 1995;280:37
5. Substituted quinolines as inhibitors of L-glutamate transport into synaptic vesicles.
   Bartlett et al.
   Neuropharmacology, 1998;37:839
6. 7-Chlorokynurenic acid is a selective antagonist of the glycine modulatory site of the NMDA receptor complex.
   Kemp et al.
   Proc.Natl.Acad.Sci.U.S.A., 1988;85:6547
7. Characterization of [³H]-glycine binding to a modulatory site within the NMDA receptor complex from rat brain.
   Donald et al.
   Br.J.Pharmacol., 1988;95:892P

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