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7-Hydroxy-DPAT hydrobromide

Catalog #: 0706 Datasheet / COA / SDS

Discontinued Product

0706 has been discontinued.
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7-Hydroxy-DPAT hydrobromide | CAS No. 76135-30-3 | Dopamine D3 Receptor Agonists
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Description: Dopamine agonist (D3 ≥ D2 < > D4)

Chemical Name: (±)-7-Hydroxy-2-dipropylaminotetralin hydrobromide

Purity: ≥99%

Product Details
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

7-Hydroxy-DPAT hydrobromide is a D3 dopamine receptor agonist (Ki values are ~ 1, 10, 650 and ~ 5000 nM for D3, D2, D4 and D1 receptors respectively).

8-Hydroxy Isomer also available.

Technical Data

M.Wt:
328.28
Formula:
C16H25NO.HBr
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
76135-30-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Dopamine inhibits the effector functions of activated NK cells via the upregulation of the D5 receptor.
    Mikulak J, Bozzo L, Roberto A, Pontarini E, Tentorio P, Hudspeth K, Lugli E, Mavilio D
    J Immunol, 2014;193(6):2792-800.
  2. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  3. Behavioural effects of the D3 DA receptor agonist 7-OH-DPAT in relation to other D2-like agonists.
    Daly and Waddington
    Neuropharmacology, 1993;32:509
  4. Aminotetralin drugs and D3 receptor fuctions.
    Levesque
    Biochem.Pharmacol., 1996;52:511
  5. Identification, characterization, and localization of the DA D3 receptor in rat brain using [3H]-7-hydroxy-N,N-di-n-propyl-2-aminotetralin.
    Levesque et al.
    Proc.Natl.Acad.Sci.U.S.A., 1992;89:8155
  6. DA receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264

Product Datasheets

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