Home / EPAC Activators / 8-CPT-2Me-cAMP, sodium salt

8-CPT-2Me-cAMP, sodium salt

Catalog #: 1645
11 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1645/1
8-CPT-2Me-cAMP, sodium salt | CAS No. 634207-53-7 | EPAC Activators
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Description: Selective Epac activator

Chemical Name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate sodium salt

Purity: ≥99%

Product Details
Citations (11)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

8-CPT-2Me-cAMP, sodium salt is a selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 > 10 μM). Stimulates Epac-mediated Ca2+-mediated Ca2+ release in pancreatic β-cells in vitro. Cell permeable analog (Cat. No. 4853) also available.

Technical Data

M.Wt:
507.82
Formula:
C17H16ClN5O6PS.Na
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
634207-53-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of BioLog Life Science Institute

Background References

  1. Role of calcium and EPAC in norepinephrine-induced ghrelin secretion.
    Mani B, Chuang J, Kjalarsdottir L, Sakata I, Walker A, Kuperman A, Osborne-Lawrence S, Repa J, Zigman J
    Endocrinology, 2014;155(1):98-107.
  2. An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer.
    Garcia-Murillas I, Sharpe R, Pearson A, Campbell J, Natrajan R, Ashworth A, Turner N
    Oncogene, 2014;33(19):2478-86.
  3. Prostacyclin regulates bone growth via the Epac/Rap1 pathway.
    Hutchison, Michele, White, Perrin C
    Endocrinology, 2015;156(2):499-510.
  4. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK.
    Enserink et al.
    Nat.Cell.Biol., 2002;4:901
  5. Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic βcells.
    Kang et al.
    J.Biol.Chem., 2003;278:8279
  6. A family of cAMP-binding proteins that directly activate Rap1.
    Kawasaki et al.
    Science, 1998;282:2275

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Citations for 8-CPT-2Me-cAMP, sodium salt

The citations listed below are publications that use Tocris products. Selected citations for 8-CPT-2Me-cAMP, sodium salt include:

11 Citations: Showing 1 - 10

  1. Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells.
    Authors: Ng
    Cell Signal  2018;51:59
  2. Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity.
    Authors: Mohan Et al.
    Endocrinology  2015;46:53
  3. Prostacyclin regulates bone growth via the Epac/Rap1 pathway.
    Authors: Hutchison and White
    PLoS One  2015;156:499
  4. An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer.
    Authors: Garcia-Murillas Et al.
    Oncogene  2014;33:2478
  5. Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions.
    Authors: Guichard Et al.
    Cell Host Microbe  2013;14:294
  6. Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity.
    Authors: Hu Et al.
    Proc Natl Acad Sci U S A  2012;109:17681
  7. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem  2011;116:984
  8. Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells.
    Authors: Soltoff and Hedden
    J Biol Chem  2010;285:13337
  9. Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death.
    Authors: Himer Et al.
    FASEB J  2010;24:2631
  10. The adenosine a2a receptor inhibits matrix-induced inflammation in a novel fashion.
    Authors: Scheibner Et al.
    Am J Respir Cell Mol Biol  2009;40:251
  11. IQGAP1 binds Rap1 and modulates its activity.
    Authors: Jeong Et al.
    J Biol Chem  2007;282:20752

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