A 33
Chemical Name: 2-[4-[[2-(5-Chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]acetic acid
Purity: ≥98%
Biological Activity
A 33 is a potent and selective PDE4B inhibitor (IC50 = 15 nM); exhibits >100-fold selectivity for PDE4B over 4D. Regulates cAMP in inflammatory cells. Inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. Reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. Also exhibits antidepressant-like effects. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery of selective PDE4B inhibitors.
Naganuma et al.
Bioorg.Med.Chem.Lett., 2009;19:3174 -
Comparison of the pharmacological profiles of selective PDE4B and PDE4D inhibitors in the central nervous system.
Zhang et al.
Sci.Rep., 2017;7:40115 -
Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury.
Wilson et al.
PLoS One, 2017;12:e0178013
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Citation for A 33
The citations listed below are publications that use Tocris products. Selected citations for A 33 include:
1 Citation: Showing 1 - 1
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PDE4B Is a Homeostatic Regulator of Cyclic AMP in Dendritic Cells.
Authors: Eyal Et al.
Front Pharmacol 2022;13:833832
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