A 784168
Chemical Name: 3,6-Dihydro-3'-(trifluoromethyl)-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-[1(2H),2'-bipyridine]-4-carboxamide
Purity: ≥99%
Biological Activity
A 784168 is a potent TRPV1 antagonist (IC50 = 25 nM for inhibition of TRPV1 activation by 50 nM capsaicin). Displays no activity against a range of receptors, including TRPA1, GABA, opioid, and purinergic receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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[3H]-A-778317 [1-((R-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor.
Bianchi et al.
J.Pharmacol.Exp.Ther., 2007;323:285 -
TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists.
Cui et al.
J.Neurosci., 2006;26:9385
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Citations for A 784168
The citations listed below are publications that use Tocris products. Selected citations for A 784168 include:
2 Citations: Showing 1 - 2
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Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels.
Authors: James Et al.
Nat Commun 2022;13:600
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Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells.
Authors: Alharris Et al.
Oncotarget 2019;10:45
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