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A 80426 mesylate

Catalog #: 2341 Datasheet / COA / SDS

Discontinued Product

2341 has been discontinued.
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A 80426 mesylate | CAS No. 152148-64-6 | Adrenergic alpha-2 Receptor Antagonists
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Description: High affinity α2 antagonist. Also 5-HT uptake inhibitor

Chemical Name: N-Methyl-N-[[(1R)-1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl]methyl]-6-benzofuranethanamine mesylate

Purity: ≥98%

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Biological Activity

A 80426 mesylate is a high affinity α2-adrenoceptor antagonist and selective 5-HT uptake inhibitor (Ki values are 2.01 and 3.77 nM respectively). Displays low affinity at a variety of structurally homologous GPCRs.

Technical Data

M.Wt:
445.57
Formula:
C23H27NO2.CH3SO3H
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
152148-64-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthesis and pharmacological characterisation of A-80426: a putative novel antidepressant combining α-2 antagonism with 5-HT uptake inhibition.
    Meyer et al.
    Bioorg.Med.Chem.Letts., 1995;5:2287
  2. A-80426, a potent and selective β2-adrenoceptor antagonist with serotonin uptake-blocking activity and putative antidepressant-like effects: II. Pharmacology profile.
    Giardina et al.
    Drug Devel.Res., 1995;35:246

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