AC 186
Chemical Name: 4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol
Purity: ≥99%
Biological Activity
AC 186 is a potent and selective ERβ agonist (EC50 values are 6 and 5000 nM for ERβ and ERα respectively). Exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease. Decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's disease.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease.
George et al.
ACS Chem.Neurosci., 2013;4:1537 -
AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model.
McFarland et al.
ACS Chem.Neurosci., 2013;4:1249
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Citation for AC 186
The citations listed below are publications that use Tocris products. Selected citations for AC 186 include:
1 Citation: Showing 1 - 1
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Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer.
Authors: Hanna S Et al.
Front Oncol 2022;12:857590
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