Home / Calcitonin and Related Receptor Antagonists / AC 187

AC 187

Catalog #: 3419
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3419/500U
AC 187
1 Image
Description: Potent and selective amylin antagonist

Purity: ≥95%

Product Details
Citations (3)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AC 187 is an orally active, potent amylin receptor antagonist (IC50 = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.

Technical Data

M.Wt:
2890.25
Formula:
C127H205N37O40
Sequence:
VLGKLSQELHKLQTYPRTNTGSNTY

(Modifications: Val-1 = N-terminal Ac, Tyr-25 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
151804-77-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antagonist of the amylin receptor blocks β-amyloid toxicity in rat cholinergic basal forebrain neurons.
    Jhamandas and MacTavish
    J.Neurosci., 2004;24:5579
  2. Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187.
    Gedulin et al.
    Regul.Pept., 2006;137:121
  3. Amylin receptor blockade stimulates food intake in rats.
    Reidelberger et al.
    Am.J.Physiol.Inter.Comp.Physiol., 2004;287:R568

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for AC 187

The citations listed below are publications that use Tocris products. Selected citations for AC 187 include:

3 Citations: Showing 1 - 3

  1. Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide.
    Authors: Nuñez-Diaz Et al.
    Mol Brain  2023;16:25
  2. The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats.
    Authors: Liberini Et al.
    Mol Metab  2016;5:834
  3. Antipsychotic-like actions of the satiety peptide, amylin, in ventral striatal regions marked by overlapping calcitonin receptor and RAMP-1 gene expression.
    Authors: Baisley Et al.
    J Neurosci  2014;34:4318

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for AC 187

There are currently no reviews for this product. Be the first to review AC 187 and earn rewards!

Have you used AC 187?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.