AC 1903
Chemical Name: N-(2-Furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine
Purity: ≥98%
Biological Activity
AC 1903 is a selective TRPC5 blocker (IC50 = 4.0 - 13.6 μM). Also displays weak inhibition at TRPC4 (IC50 >100 μM) but not TRPC6. Exhibits no effect against a standard panel of profiling kinases. Blocks TRPC5 channel activity in glomeruli of proteinuric rats. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis (FSGS).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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TRP'ing up chronic kidney disease.
Chung et al.
Science, 2017;358:1256 -
A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.
Zhou et al.
Science, 2017;358:1332 -
Remarkable progress with small-molecule modulation of TRPC1/4/5 channels: implications for understanding the channels in health and disease.
Minard et al.
Cells, 2018;7:doi: 10.3390
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