Ac-LEHD-AFC

Name: Ac-LEHD-AFC
Brand: Tocris Bioscience
SKU: 1575

Catalog #: 1575 Datasheet / COA / SDS

Discontinued Product

1575 has been discontinued.

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Description: Fluorogenic caspase substrate

Chemical Name: N-Acetyl-Leu-Glu-His-Asp-(7-amino-4-trifluoromethylcoumarin)

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Product Details

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.

Technical Data

M.Wt:

765.7

Formula:

C₃₃H₃₈F₃N₇O₁₁

Sequence:

LEHD

(Modifications: Leu-1 = N-Ac-Leu, Asp-4 = Asp-(7-amino-4-trifluoromethylcoumarin))

Solubility:

Soluble to 1 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

210345-03-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Possible involvement of cytochrome c release and sequential activation of caspases in ceramide-induced apoptosis in SK-N-MC cells.
Ito et al.
Biochim.Biophys.Acta, 1999;1452:263
Mechanism of nitric oxide-induced apoptosis in human neuroblastoma SH-SY5Y cells.
Moriya et al.
FEBS Lett., 2000;484:253

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