[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)
![[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)](https://resources.rndsystems.com/images/datasheets/structures/ac-tyr1-d-phe2grf-1-29-amide-human_1172.png "[Ac-Tyr1,D-Phe2]GRF 1-29, amide (human)")
Biological Activity
VIP receptor antagonist; inhibits [125I]iodo-VIP binding and selectively inhibits VIP- and GRF-induced effects on adenylyl cyclase.Technical Data
(Modifications: Tyr-1 = N-terminal Ac, Phe-2 = D-Phe, Arg-29 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Evidence that endogenous vasoactive intestinal peptide (VIP) is involved in the regulation of rat pituitary-adrenocortical function: in vivo studies with a VIP antagonist.
Nowak et al.
Neuropeptides, 1994;27:297 -
Interaction of GH-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist.
Waelbroeck et al.
Endocrinology, 1985;116:2643
Product Datasheets
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