Acarbose
Chemical Name: O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1-4)-O-α-D-glucopyranosyl-(1-4)-D-Glucose
Biological Activity
Acarbose is an inhibitor of intestinal α-glucosidase (IC50 = 11 nM). Antidiabetic; inhibits the hydrolysis of complex carbohydrates.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Acarbose: an update of its pharmacology and therapeutic use in diabetes mellitus.
Balfour and McTavish
Drugs, 1993;46:1025 -
Evaluation of alpha-glucosidase inhibition by using an immobilized assay system.
Oki et al.
Biol.Pharm.Bull., 2000;23:1084 -
Inhibition of disaccharide digestion in rat intestine by the alpha-glucosidase inhibitor aca. (BAY g 5421).
Krause et al.
Digestion, 1982;23:232
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