ACPT-II
Chemical Name: (1R,3R,4S)-1-Aminocyclopentane-1,3,4-tricarboxylic acid
Biological Activity
ACPT-II is a competitive metabotropic receptor antagonist (KB values are 115, 88 and 77 μM at mGlu1a, mGlu2 and mGlu4a respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.
Acher et al.
J.Med.Chem., 1997;40:3119 -
Closure of the venus flytrap model of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists.
Bessis et al.
Proc.Natl.Acad.Sci.U.S.A., 2002;99:11097
Product Datasheets
Citations for ACPT-II
The citations listed below are publications that use Tocris products. Selected citations for ACPT-II include:
2 Citations: Showing 1 - 2
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HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Authors: Scholler
Nat Chem Biol 2017;13(4):372
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Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse.
Authors: Casado Et al.
Int J Mol Sci 2000;97:11593
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