ACT 335827

Catalog #: 4983 Datasheet / COA / SDS

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ACT 335827 | CAS No. 1354039-86-3 | OX1 Receptor Antagonists

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Description: Potent and selective OX1 antagonist

Chemical Name: (aR,1S)-1-[(3,4-Dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy-N-(1-methylethyl)-a-phenyl-2(1H)-isoquinolineacetamide

Purity: ≥98%

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Biological Activity

ACT 335827 is a potent and selective orexin OX₁ receptor antagonist (K_b values are 41 and 560 nM for OX₁ and OX₂ receptors respectively). Elicits anxiolytic effects in vivo. Brain penetrant and orally available.

Technical Data

M.Wt:

518.64

Formula:

C₃₁H₃₈N₂O₅

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

1354039-86-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Discovery and characterization of ACT-335827, an orally available, brain penetrant orexin receptor type 1 selective antagonist.
Steiner et al.
ChemMedChem, 2013;8:898

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