ACTH (1-39)
Purity: ≥95%
Biological Activity
ACTH (1-39) is a potent endogenous melanocortin receptor 2 (MC2) agonist (EC50 = 57 pM). Component of the hypothalamic-pituitary-adrenal (HPA) axis that stimulates glucocorticoid production and release from the adrenal cortex. Induces insulin resistance, promotes a proinflammatory profile and stimulates UCP-1 in adipocytes in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
The atherogenic Scarb1 null mouse model shows a high bone mass phenotype.
Martineau C, Martin-Falstrault L, Brissette L, Moreau R
Am J Physiol Endocrinol Metab, 2014;306(1):E48-57. -
Agonist and receptor binding properties of adrenocorticotropin peptides using the cloned mouse adrenocorticotropin receptor expressed in a stably transfected HeLa cell line.
Kapas et al.
Endocrinology, 1996;137:3291 -
Melanocortin crosstalk with adipose functions: ACTH directly induces Ins resistance, promotes a pro-inflammatory adipokine profile and stimulates UCP-1 in adipocytes.
Iwen et al.
J.Endocrinol., 2008;196:465 -
Brain effects of melanocortins.
Bertolini et al.
Pharmacol.Res., 2009;59:13
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for ACTH (1-39)
The citations listed below are publications that use Tocris products. Selected citations for ACTH (1-39) include:
4 Citations: Showing 1 - 4
-
Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain.
Authors: Ewa Et al.
Pain 2021;162:432-445
-
Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro.
Authors: Nepomuceno Et al.
Front Pharmacol 2018;9:157
-
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.
Authors: Nøhr Et al.
Neurochem Int 2017;102:105
-
The atherogenic Scarb1 null mouse model shows a high bone mass phenotype.
Authors: Martineau Et al.
Am J Physiol Endocrinol Metab 2014;306:E48
FAQs
No product specific FAQs exist for this product, however you may
View all Peptide FAQsReviews for ACTH (1-39)
There are currently no reviews for this product. Be the first to review ACTH (1-39) and earn rewards!
Have you used ACTH (1-39)?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
