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Actinomycin D

Catalog #: 1229
19 Citations Datasheet / COA / SDS
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1229/10
Actinomycin D | CAS No. 50-76-0 | RNA/DNA Polymerase Inhibitors
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Description: Inhibits RNA polymerase

Chemical Name: 2-Amino-(N,N)-1-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1]-[1,4,7,10,13] oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide

Purity: ≥95%

Product Details
Citations (19)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Actinomycin D is an anti-neoplastic antibiotic. Inhibits RNA polymerase and is a potent inducer of apoptosis.

Technical Data

M.Wt:
1255.43
Formula:
C62H86N12O16
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
50-76-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Direct regulation of the proglucagon gene by insulin, leptin, and cAMP in embryonic versus adult hypothalamic neurons.

    Mol. Endocrinol., 2102;26(8):1339-55.
  2. Purinergic P2Y2 Receptor Control of Tissue Factor Transcription in Human Coronary Artery Endothelial Cells: NEW AP-1 TRANSCRIPTION FACTOR SITE AND NEGATIVE REGULATOR.
    Liu Y, Zhang L, Wang C, Roy S, Shen J
    J Biol Chem, 2016;291(4):1553-63.
  3. Frontline Science: c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection
    R Connor, LD Jones, X Qiu, J Thakar, SB Maggirwar
    J. Leukoc. Biol., 2017;0(0):.
  4. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
    Wang C, Held R, Hall B
    PLoS ONE, 2013;8(12):e83941.
  5. Targeting the stress oncoprotein LEDGF/p75 to sensitize chemoresistant prostate cancer cells to taxanes
    L Ríos-Colón, CK Cajigas-Du, A Basu, C Elix, I Alicea-Pol, TW Sanchez, V Radhakrish, CS Chen, CA Casiano
    Oncotarget, 2017;8(15):24915-24931.
  6. A kinetic study on the mechanism of inhibition of RNA synthesis catalyzed by DNA-dependent RNA polymerase. Differences in inhibition by ethidium bromide, 3,8-diamino-6-ethylphenanthridinium bromide and actinomycin D.
    Aktipis et al.
    Biochim.Biophys.Acta, 1981;655:278
  7. Apoptosis induced by actinomycin D, camptothecin or aphidicolin can occur in all phases of the cell cycle.
    Glynn et al.
    Biochem.Soc.Trans., 1992;20:84S
  8. The mechanism of actinomycin D-mediated inhibition of HIV-1 reverse transcription.
    Jeeninga et al.
    Nucleic Acids Res., 1998;26:5472

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⚠ WARNING: This product can expose you to chemicals including Actinomycin D, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov

Citations for Actinomycin D

The citations listed below are publications that use Tocris products. Selected citations for Actinomycin D include:

19 Citations: Showing 1 - 10

  1. Structural determinants and genetic modifications enhance BMP2 stability and extracellular secretion.
    Authors: Khattar Et al.
    FASEB Bioadv  2019;1:180
  2. Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.
    Authors: Livingstone Et al.
    Front Mol Neurosci  2019;12:198
  3. Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome.
    Authors: Thomson Et al.
    Neuron  2017;95:550
  4. Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala.
    Authors: Di Et al.
    J.Neurosci.  2016;36:8461
  5. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
    Authors: Visavadiya
    Cell Communication and Signaling  2016;14:32
  6. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
    Authors: Wang Et al.
    PLoS One  2014;8:e83941
  7. Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions.
    Authors: Parker and Kooi
    J Biol Chem  2014;453:42525
  8. The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.
    Authors: Gutierrez Et al.
    J Biol Chem  2014;289:33568
  9. Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation.
    Authors: Podszywalow-Bartnicka Et al.
    Cardiovasc Res  2014;13:3727
  10. Endocannabinoid-dependent long-term depression in a nociceptive synapse requires coordinated presynaptic and postsynaptic transcription and translation.
    Authors: Yuan and Burrell
    J Neurosci  2013;33:4349
  11. Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice.
    Authors: Kang Et al.
    J Neurosci  2012;32:9277
  12. Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice.
    Authors: Cheang Et al.
    Biochem Biophys Res Commun  2011;92:267
  13. MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons.
    Authors: Tian Et al.
    Mol Cell Neurosci  2010;44:94
  14. Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
    Authors: Huang Et al.
    J Neurosci  2010;30:6080
  15. Posttranscriptional regulation of angiotensin II type 1 receptor expression by glyceraldehyde 3-phosphate dehydrogenase.
    Authors: Backlund Et al.
    Nucleic Acids Res  2009;37:2346
  16. Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging.
    Authors: Wong Et al.
    Circ Res  2009;104:228
  17. p100 increases AT1R expression through interaction with AT1R 3'-UTR.
    Authors: Paukku Et al.
    Nucleic Acids Res  2008;36:4474
  18. Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem death.
    Authors: Chan Et al.
    Cell Cycle  2007;282:4585
  19. Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation.
    Authors: Vecsey Et al.
    J Neurosci  2007;27:6128

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