AICAR

Tocris Bioscience | Catalog # 2840

AMPK activator
Tocris Bioscience

Key Product Details

Description

AMPK activator
View all AMPK Activators »

Product Description

AICAR is a cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro.

Product Specifications for AICAR

Molecular Weight

258.23

Formula

C9H14N4O5

Storage

Store at -20°C

Purity

≥99% (HPLC)

Chemical Name

N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide

CAS Number

2627-69-2

PubChem ID

17513

InChI Key

RTRQQBHATOEIAF-UUOKFMHZSA-N

SMILES

O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC(C(N)=O)=C2N)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.37 75
DMSO 19.37 75

Preparing Stock Solutions for AICAR

The following data is based on the product molecular weight 258.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 5.16 mL 25.82 mL 51.63 mL
3.75 mM 1.03 mL 5.16 mL 10.33 mL
7.5 mM 0.52 mL 2.58 mL 5.16 mL
37.5 mM 0.10 mL 0.52 mL 1.03 mL

Calculators

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Product Documents for AICAR

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AICAR

For research use only

Related Research Areas

Autophagy
Intracellular Kinases
Obesity

Customer Reviews for AICAR (1)

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  • good product, satisfied
    Name: Kishor Pant
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 05/22/2019
    Cancer and normal cell lines treated with 2mM for different times and we noticed modulation in the AMPK and p53 expression.
    AICAR 2840

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