AIDA
Chemical Name: (RS)-1-Aminoindan-1,5-dicarboxylic acid
Purity: ≥98%
Biological Activity
AIDA is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a), having no effect on group II (mGlu2) or group III (mGlu4) receptors expressed individually in baby hamster kidney cells. Has no effect on ionotropic glutamate receptors. Centrally active following systemic administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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N-acetylcysteine protects against apoptosis through modulation of group I metabotropic glutamate receptor activity.
Sun L, Gu L, Wang S
PLoS ONE, 2012;7(3):e32503. -
Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors.
Ady V, Perroy J, Tricoire L, Piochon C, Dadak S, Chen X, Dusart I, Fagni L, Lambolez B, Levenes C
EMBO Rep, 2014;15(1):103-9. -
1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors.
Pellicciari et al.
J.Med.Chem., 1995;38:3717 -
Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist.
Moroni et al.
J.Pharmacol.Exp.Ther., 1997;281:721 -
Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats.
Nielsen et al.
Eur.J.Pharmacol., 1997;326:105
Product Datasheets
Citations for AIDA
The citations listed below are publications that use Tocris products. Selected citations for AIDA include:
9 Citations: Showing 1 - 9
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Glutamate signals through mGluR2 to control Schwann cell differentiation and proliferation
Authors: Saitoh Et al.
Scientific Reports 2016;6:29856
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Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
Authors: Mahler Et al.
Proc Natl Acad Sci U S A 2014;19:49
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Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 δ glutamate receptors.
Authors: Ady Et al.
J Neurosci 2014;15:103
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Cell type-specific regulation of inhibition via cannabinoid type 1 receptors in rat neocortex.
Authors: De-May and Ali
J Neurophysiol 2013;109:216
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Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals.
Authors: Cassé Et al.
J Neurosci 2012;32:5186
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Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo.
Authors: Wibrand Et al.
Eur J Neurosci 2010;31:636
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Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
Authors: Shin Et al.
EMBO Rep 2008;105:746
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Effects of the group I metabotropic glutamate receptor agonist, DHPG, and injection stress on striatal cell signaling in food-restricted and ad libitum fed rats.
Authors: Pan Et al.
BMC Neurosci 2004;5:50
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Multiple forms of LTP in hippocampal CA3 neurons use a common postsynaptic mechanism.
Authors: Yeckel Et al.
Nat Neurosci 1999;2:625
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