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AKOS 022

Catalog #: 7135 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7135/50
7135/10
AKOS 022 | CAS No. 878983-38-1 | Ion Channel Modulators
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Description: Voltage-dependent anion channel (VDAC) inhibitor

Chemical Name: 1-(4-Chlorophenyl)-3-[4-[[4-(trifluoromethoxy)phenyl]amino]-1-piperidinyl]-2,5-pyrrolidinedione

Purity: ≥98%

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Biological Activity

AKOS 022 is a voltage-dependent anion channel (VDAC; Kd = 154 μM) inhibitor, which reduces channel conductance. In HEK-293 cells, AKOS 022 inhibits selenium-induced VDAC oligomerization, cytochrome C release from mitochondria and apoptosis (IC50 values range from 3.3 to 3.6 μM). AKOS 022 also prevents glucotoxicity-mediated overexpression of VDAC1 in INS-1 cells.

Technical Data

M.Wt:
467.87
Formula:
C22H21ClF3N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
878983-38-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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