Home / OX2 Receptor Agonists / [Ala11,D-Leu15]-Orexin B

[Ala11,D-Leu15]-Orexin B

Catalog #: 2142
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2142/1
[Ala11,D-Leu15]-Orexin B
1 Image
Description: Potent and selective OX2 agonist

Purity: ≥95%

Product Details
Citations (4)
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Biological Activity

[Ala11,D-Leu15]-Orexin B is a highly potent and selective OX2 receptor agonist; displays 400-fold selectivity over OX1 receptors. EC50 values are 0.13 and 52 nM for human OX2 and OX1 receptors respectively.

Technical Data

M.Wt:
2857.28
Formula:
C120H206N44O35S
Sequence:
RSGPPGLQGRAQRLLQASGNHAAGILTM

(Modification: Leu-15 = D-Leu, Met-28 = C-terminal amide)

Solubility:
Soluble to 0.30 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
532932-99-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Development of an orexin-2 receptor selective agonist, [Ala11D-Leu15]orexin-B.
    Asahi et al.
    Bioorg.Med.Chem.Lett., 2003;13:111

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Citations for [Ala11,D-Leu15]-Orexin B

The citations listed below are publications that use Tocris products. Selected citations for [Ala11,D-Leu15]-Orexin B include:

4 Citations: Showing 1 - 4

  1. Effects of orexin 2 receptor activation on apnea in the C57BL/6J mouse.
    Authors: Moore Et al.
    Respir Physiol Neurobiol  2014;200:118
  2. OX2R activation induces PKC-mediated ERK and CREB phosphorylation.
    Authors: Guo and Feng
    Exp Cell Res  2012;318:2004
  3. Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex.
    Authors: Shahid Et al.
    Br J Pharmacol  2012;165:2292
  4. Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor.
    Authors: Malherbe Et al.
    Br J Pharmacol  2009;156:1326

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