Alfuzosin hydrochloride
Discontinued Product
Chemical Name: N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide hydrochloride
Purity: ≥99%
Biological Activity
Alfuzosin hydrochloride is a functionally uro-selective α1 adrenoceptor antagonist that does not discriminate between α1 subtypes. Inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascular effects. Also relaxes corpus cavernosum tissue (pIC50 = 7.64) in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Alfuzosin hydrocholride for the treatment of benign prostatic hyperplasia.
Lee
Am.J.Health Syst.Pharm., 2003;60:1426 -
Effects of different alpha-1 adrenoceptor blockers on proximal urethral function using in vivo isovolumetric pressure changes.
Yamaguchi et al.
J.Smooth Muscle Res., 2005;41:247 -
Comparison of the relaxant effects of alfuzosin, phentol. and silde. on rabbit isolated corpus cavernosum.
Palea and Barras
BJU Int., 2003;91:873
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