AMBMP hydrochloride
Chemical Name: N4-(1,3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride
Purity: ≥98%
Biological Activity
AMBMP hydrochloride is a Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer cells. Also decreases embryo to blastocyst development.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A small-molecule agonist of the Wnt signaling pathway.
Liu et al.
Angew.Chem.Int.Ed.Engl., 2005;44:1987 -
2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes.
Wang et al.
Inflamm.Res., 2016;65:61 -
Tubulin is a molecular target of the Wnt-activating chemical probe.
Fukuda et al.
BMC Biochem., 2016;17:9 -
Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage.
Denicol et al.
Sci.Rep., 2013;3:1266
Product Datasheets
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Citation for AMBMP hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for AMBMP hydrochloride include:
1 Citation: Showing 1 - 1
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SLC6A14, a Na+/Cl--coupled amino acid transporter, functions as a tumor promoter in colon and is a target for Wnt signaling.
Authors: Vadivel Et al.
Biochem J 2020;477:1409-1425
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