Amiodarone hydrochloride

Biological Activity

Amiodarone hydrochloride is a broad-spectrum ion channel blocker; blocks late I_Na, I_Ca, I_Kr and I_Ks and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca²⁺ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. Selectively toxic to NSCs in hESC-derived cell populations. Amiodarone depolarizes the resting membrane potential of the triple-negative breast cancer (TNBC) cells and decreases cell migration.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Activation of NLRP3 inflammasome by crystalline structures via cell surface contact.
   Hari A, Zhang Y, Tu Z, Detampel P, Stenner M, Ganguly A, Shi Y
   Sci Rep, 2014;4(0):7281.
2. Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not DA neurons.
   Han et al.
   PLoS One., 2009;4:7155
3. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling.
   Balgi et al.
   PLoS One, 2009;4:e7124
4. Amiodarone induces cytochrome c release and apoptosis through an iodine-dependent mechanism.
   di Matola et al.
   J.Clin.Endocrin.Metab., 2000;85:4323
5. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties.
   Antzelevitch et al.
   Circulation, 2004;110:904

Product Datasheets