Amlodipine besylate
Chemical Name: 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate
Purity: ≥98%
Biological Activity
Amlodipine besylate is a L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50 = 25 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Antiproliferative effect of Ca2+ channel blockers on human epidermoid carcinoma A431 cells.
Yoshida et al.
Eur.J.Pharmacol., 2003;472:23 -
Calcium channel blocking properties of amlod. in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors.
Burges et al.
J.Cardiovasc.Pharmacol., 1987;9:110 -
Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the NG-nitro-L-arginine methyl ester-induced hype
Toba et al.
Hypertens.Res., 2005;28:689
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Citations for Amlodipine besylate
The citations listed below are publications that use Tocris products. Selected citations for Amlodipine besylate include:
2 Citations: Showing 1 - 2
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Suppression of protective responses upon activation of L-type voltage gated calcium channel in macrophages during mycobacterium bovis BCG infection
Authors: Sharma Et al.
PLoS One 2016;11:e0163845
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Serotonin 5-HT3 receptor-mediated vomiting occurs via the activation of Ca2+/CaMKII-dependent ERK1/2 signaling in the least shrew (Cryptotis parva).
Authors: Zhong Et al.
PLoS One 2014;9:e104718
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