Home / Group III mGluR Agonists / AMN 082 dihydrochloride

AMN 082 dihydrochloride

Catalog #: 2385
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2385/10
2385/50
AMN 082 dihydrochloride | CAS No. 97075-46-2 | Group III mGluR Agonists
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Description: Selective mGlu7 agonist

Chemical Name: N,N'-Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride

Purity: ≥99%

Product Details
Citations (3)
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Biological Activity

AMN 082 dihydrochloride is a the first selective mGlu7 agonist. Potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μM. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats.

View important information regarding the usage of AMN 082 dihydrochloride.

Technical Data

M.Wt:
465.45
Formula:
C28H28N2.2HCl
Solubility:
Soluble to 100 mM in DMSO and to 2 mM in water with gentle warming
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
97075-46-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease.
    Greco et al.
    J.Pharmacol.Exp.Ther., 2010;332:1064
  2. AMN082, the first selective mGluR7 agonist: activation of receptor signaling via an allosteric site in the transmembrane domain modulates stress parameters in vivo.
    Flor et al.
    Neuropharmacology, 2005;49:244
  3. A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo.
    Mitsukawa et al.
    Proc.Natl.Acad.Sci.USA, 2005;102:18712

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Citations for AMN 082 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for AMN 082 dihydrochloride include:

3 Citations: Showing 1 - 3

  1. Activating metabotropic glutamate receptor-7 attenuates visceral hypersensitivity in neonatal maternally separated rats.
    Authors: Shao Et al.
    Int J Mol Med  2019;43:761
  2. New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection.
    Authors: Jantas Et al.
    Neuropharmacology  2018;141:223
  3. Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata.
    Authors: Broadstock Et al.
    Br J Pharmacol  2012;165:1034

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