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Amphotericin B

Catalog #: 6930 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6930/100
Amphotericin B | CAS No. 1397-89-3 | General Laboratory Research Reagent
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Description: Forms monovalent ion channels in lipid bilyers; antifungal

Chemical Name: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid

Purity: ≥90%

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Biological Activity

Amphotericin B forms nonselective monovalent ion channels within lipid bilayers. Amphotericin B binds ergosterol in the cell membrane. Antifungal and antiprotozoal.

For more information about how Amphotericin B may be used, see our protocol:

3D Culture of Lung Alveolar Cells

Technical Data

M.Wt:
924.09
Formula:
C47H73NO17
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥90%
Storage:
Store at -20°C
CAS No:
1397-89-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia.
    Muruglia et al.
    Nature., 2019;567:405
  2. Amphotericin B: 30 years of clinical experience.
    Gallis et al.
    Rev.Infect.Dis., 1990;12:308
  3. Current concepts in antifungal pharmacology.
    Lewis
    Mayo Clin.Proc., 2011;86:805

Product Datasheets

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