Amthamine dihydrobromide
Chemical Name: 2-Amino-5-(2-aminoethyl)-4-methylthiazole dihydrobromide
Purity: ≥99%
Biological Activity
Amthamine dihydrobromide is a highly selective H2 agonist, slightly more potent than histamine itself. Only a weak antagonist at H3 and has no activity at H1 receptors. Induces vasodilation of cerebral arteries and decreases myogenic tone in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Histamine induces proliferation in keratinocytes from patients with atopic dermatitis through the histamine 4 receptor.
Glatzer F, Gschwandtner M, Ehling S, Rossbach K, Janik K, Klos A, Baumer W, Kietzmann M, Werfel T, Gutzmer R
J Allergy Clin Immunol, 2013;132(6):1358-67. -
Histamine H(2) receptor signaling x environment interactions determine susceptibility to experimental allergic encephalomyelitis.
Saligrama N, Case L, Krementsov D, Teuscher C
FASEB J, 2014;28(4):1898-909. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazole.
Eriks et al.
J.Med.Chem., 1992;35:3239 -
The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion.
Coruzzi et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1993;348:77 -
Histamine decreases myogenic tone in rat cerebral arteries by H2-receptor-mediated Kv channel activation, independent of endothelium and cyclic AMP.
Jarajapu et al.
Eur.J.Pharmacol., 2006;547:116 -
In vitro cardiac pharmacology of the new histamine H2 receptor agonist amthamine; comparisons with histamine and dimaprit.
Poli et al.
Agents Actions, 1993;40:44
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Citations for Amthamine dihydrobromide
The citations listed below are publications that use Tocris products. Selected citations for Amthamine dihydrobromide include:
4 Citations: Showing 1 - 4
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Histamine H2 receptor signaling � environment interactions determine susceptibility to experimental allergic encephalomyelitis.
Authors: Saligrama Et al.
FASEB J 2014;28:1898
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Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation.
Authors: Copsel Et al.
J Biol Chem 2011;286:6979
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Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4.
Authors: Chigaev Et al.
J Biol Chem 2011;286:20375
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Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP.
Authors: Flamand Et al.
Br J Pharmacol 2004;141:552
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