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Ani 9

Catalog #: 6076
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6076/50
6076/10
Ani 9 | CAS No. 356102-14-2 | Calcium-activated Chloride Channel Blockers
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Description: Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker

Chemical Name: 2-(4-Chloro-2-methylphenoxy)-N'-(2-methoxybenzylidene)acetohydrazide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Ani 9 is a potent and selective TMEM16A (Anoctamin-1; ANO1) blocker (IC50 = 77 nM). Displays no effect on ANO2 activity (at 10 μM). Also exhibits no effect on intracellular calcium signaling or CFTR and ENaC channel activity (at 30 μM).

Technical Data

M.Wt:
332.78
Formula:
C17H17ClN2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
356102-14-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Ani9, a novel potent small-molecule ANO1 inhibitor with negligible effect on ANO2.
    Seo et al.
    PLoS One, 2016;11:e0155771

Product Datasheets

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Citations for Ani 9

The citations listed below are publications that use Tocris products. Selected citations for Ani 9 include:

2 Citations: Showing 1 - 2

  1. The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca2+-release in mouse bronchial smooth muscle cells
    Authors: Dwivedi Et al.
    Eur J Pharmacol  2023;
  2. ANO1 Expression Orchestrates p27Kip1/MCL1-Mediated Signaling in Head and Neck Squamous Cell Carcinoma.
    Authors: Heikki Et al.
    Cancers (Basel)  2021;13

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