AP 811
Purity: ≥95%
Biological Activity
AP 811 is a high affinity, selective ANP clearance receptor (NPR3) antagonist (Ki = 0.45 nM). Exhibits >20,000-fold selectivity for NPR3 over NPR1. Inhibits ANP-stimulated Na+/K+ pump activity in rabbit ventricular cardiomyocytes in vitro. Also blocks proliferation of rodent neonatal cardiomyocytes seen at low ANP concentrations in vitro.Technical Data
(Modifications: Arg-1 = N2-[4-(2-Naphthoylamino)phenylacetyl], Arg-4 = C-terminal (S)-2-methylbutylamide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1.
Veale et al.
Bioorg.Med.Chem.Lett., 2000;10:1949 -
Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation.
William et al.
Am.J.Physiol.Cell Physiol., 2008;294:C1067 -
Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development.
Becker et al.
Development, 2014;141:335
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for AP 811
The citations listed below are publications that use Tocris products. Selected citations for AP 811 include:
2 Citations: Showing 1 - 2
-
Atrial Natriuretic Peptide Promotes Neurite Outgrowth and Survival of Cochlear Spiral Ganglion Neurons in vitro Through NPR-A/cGMP/PKG Signaling.
Authors: Wei Et al.
Front Cell Dev Biol 2021;9:681421
-
C-Type Natriuretic Peptide Ameliorates Vascular Injury and Improves Neurological Outcomes in Neonatal Hypoxic-Ischemic Brain Injury in Mice.
Authors: Zhen Et al.
Int J Mol Sci 2021;22
FAQs
No product specific FAQs exist for this product, however you may
View all Peptide FAQsReviews for AP 811
There are currently no reviews for this product. Be the first to review AP 811 and earn rewards!
Have you used AP 811?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
