APETx2

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target
   
   Sci Rep, 2016;6(0):37360.
2. A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins.
   Peigneur et al.
   FASEB J., 2012;26:5141
3. Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases.
   Xiong et al.
   Curr.Opin.Pharmacol., 2008;8:25
4. Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2.
   Karczewski et al.
   Br.J.Pharmacol., 2010;161:950
5. A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons.
   Diochot et al.
   EMBO J., 2004;23:1516
6. Inhibition of voltage-gated Na(+) currents in sensory neurones by the sea anemone toxin APETx2.
   Blanchard et al.
   Br.J.Pharmacol., 2012;165:2167

Product Datasheets