ARC 239 dihydrochloride
Chemical Name: 2-[2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride
Purity: ≥98%
Biological Activity
ARC 239 dihydrochloride is a selective α2B adrenoceptor antagonist (pKD values are 8.8, 6.7 and 6.4 at α2B, α2A, and α2D receptors respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Alpha-2A and alpha-2B adrenergic subtypes: antagonist binding in tissues and cell lines containing only one subtype.
Bylund et al.
J.Pharmacol.Exp.Ther., 1988;245:600 -
Characterisation of sensory neurotransmission and its inhibition via α2B-adrenoceptors and via non-α2 adrenoceptors in rabbit iris.
Fuder and Selback
Naunyn Schmiedebergs Arch.Pharmacol., 1993;347:394
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Citation for ARC 239 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for ARC 239 dihydrochloride include:
1 Citation: Showing 1 - 1
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The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
Authors: Kahn Et al.
EMBO Mol Med 2016;8:511
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