Artemether
Chemical Name: (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
Purity: ≥98%
Biological Activity
Artemether is an antimalarial. Prevents cerebral malaria in Plasmodium berghei infected mice. Exhibits synergistic effects with Methylene Blue (Cat. No. 3213) against P. falciparum in vitro. Inhibits neuroinflammation in neuronal/microglial cell co-cultures via induction of Nrf2 expression.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins.
Akoachere et al.
Antimicrob.Agents Chemother., 2005;49:4592 -
Antimalarial drug artem. inhibits neuroinflammation in BV2 microglia through Nrf2-dependent mechanisms.
Okorji et al.
Mol.Neurobiol., 2015;53 -
Upregulation of reactive oxygen and nitrogen intermediates in Plasmodium berghei infected mice after rescue therapy with chloroquine or artem.
Prada et al.
J.Antimicrob.Chemother., 1996;38:95
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