Artesunate
Chemical Name: 4-Oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic acid
Purity: ≥98%
Biological Activity
Artesunate suppresses ROS-induced activation of the NLRP3 inflammasome. Arrests cell cycle in the G2/M phase and sensitizes human renal cell carcinoma (RCC) cell lines to sorafenib in vitro. Aretesumate is an antimalarial (Plasmodium).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Artemisinin: mechanisms of action, resistance and toxicity.
Meshnick et al.
In.J.Parasitol., 2002;32:1655 -
Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis.
Jeong et al.
Oncotarget., 2015;6:33046 -
Artesunate inhibits renal ischemia-reperfusion-mediated remote lung inflammation through attenuating ROS-induced activation of NLRP3 inflammasome.
Liu et al.
Inflammation, 2018;41:1546
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