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ASP 7663

Catalog #: 5178
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5178/10
5178/50
ASP 7663 | CAS No. 1190217-35-6 | TRPA1 Activators
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Description: Selective TRPA1 activator

Chemical Name: (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ASP 7663 is a selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat). Displays little or no affinity at more than 60 other related receptors, channels and enzymes. Stimulates 5-HT release from QGP-1 cells. Exhibits an abdominal analgesic effect in vivo. Orally bioavailable.

Technical Data

M.Wt:
263.26
Formula:
C14H14FNO3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1190217-35-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for ASP 7663

The citations listed below are publications that use Tocris products. Selected citations for ASP 7663 include:

2 Citations: Showing 1 - 2

  1. A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery.
    Authors: Ko Et al.
    Sci Rep  2019;9:2430
  2. Bladder Dysfunction in an Obese Zucker Rat: The Role of TRPA1 Channels, Oxidative Stress, and Hydrogen Sulfide.
    Authors: Blaha Et al.
    Oxid Med Cell Longev  2019;2019:5641645

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