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AY 9944 dihydrochloride

Catalog #: 1639
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AY 9944 dihydrochloride | CAS No. 366-93-8 | Hedgehog Signaling Inhibitors
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Description: Inhibitor of Hedgehog (Hh) signaling. Inhibits Δ7-dehydrocholesterol reductase

Chemical Name: trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride

Purity: ≥99%

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Citations (1)
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Biological Activity

AY 9944 dihydrochloride is an inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ7-dehydrocholesterol reductase (IC50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo.

Technical Data

M.Wt:
464.3
Formula:
C22H28Cl2N2.2HCl
Solubility:
Soluble to 50 mM in water and to 5 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
366-93-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Teratogen-mediated inhibition of target tissue response to Shh signaling.
    Cooper et al.
    Science, 1998;280:1603
  2. Cholesterol in signal transduction.
    Incardona and Eaton
    Curr.Opin.Cell Biol., 2000;12:193
  3. Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944.
    Kraml et al.
    Biochem.Biophys.Res.Commun., 1964;15:455
  4. Molecular cloning and expression of the human Δ7-sterol reductase.
    Moebius et al.
    Proc.Natl.Acad.Sci.U.S.A., 1998;95:1899

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Citation for AY 9944 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for AY 9944 dihydrochloride include:

1 Citation: Showing 1 - 1

  1. Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons.
    Authors: Kant Et al.
    Cell Stem Cell  2019;24:363

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