AY-NH₂

Catalog #: 1487
4 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
1487/1

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Description: Selective PAR4 agonist

Alternative Names: AYPGKF-NH₂

Purity: ≥95%

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Product Details

Citations (4)

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Biological Activity

AY-NH₂ is a selective PAR₄ receptor agonist peptide. Stimulates platelet aggregation in vitro (EC₅₀ = 15 μM). Exhibits an increase in paw thickness in the paw edema inflammation model in vivo.

Technical Data

M.Wt:

680.8

Formula:

C₃₄H₄₈N₈O₇

Sequence:

AYPGKF

(Modifications: Phe-6 = C-terminal amide)

Solubility:

Soluble to 2 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

352017-71-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo.
Hollenberg et al.
Br.J.Pharmacol., 2004;143:443
Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides.
Hollenberg and Saifeddine
Can.J.Physiol.Pharmacol., 2001;79:439
Structure-function analysis of protease-activated receptor 4 tethered ligand peptides.
Faruqi et al.
J.Biol.Chem., 2000;275:19728

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Citations for AY-NH₂

The citations listed below are publications that use Tocris products. Selected citations for AY-NH₂ include:

4 Citations: Showing 1 - 4

Expression and Purification of Protease-Activated Receptor 4 (PAR4) and Analysis with Histidine Hydrogen-Deuterium Exchange.
Authors: de la Fuente Et al.
Biochemistry 2020;59:671
Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function.
Authors: Peng Et al.
Front Immunol 2019;10:1311
Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4.
Authors: Wang
Proc Natl Acad Sci U S A 2017;114(41):10948
Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
Authors: Shi Et al.
Oncogene 2015;21:4852

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AY-NH2