AZD 1283
Chemical Name: Ethyl 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylate
Purity: ≥98%
Biological Activity
AZD 1283 is a potent and high affinity P2Y12 antagonist (IC50 = 11 nM in radioligand competition binding assay, and 25 nM in a GTPγS binding assay). Causes a dose-dependent increase in blood flow and inhibits ADP-induced platelet aggregation in vivo. Antithrombotic.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.
Bach et al.
J.Med.Chem., 2013;56:7015 -
Agonist-bound structure of the human P2Y12 receptor.
Zhang et al.
Nature, 2014;509:119 -
Structure of the human P2Y12 receptor in complex with an antithrombotic drug.
Zhang et al.
Nature, 2014;509:115
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