Home / Other ER Stress/UPR Inhibitors / AZD 5582 dihydrochloride

AZD 5582 dihydrochloride

Catalog #: 5141
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5141/10
AZD 5582 dihydrochloride | CAS No. 1883545-51-4 | Other ER Stress/UPR Inhibitors
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Description: Dimeric Smac mimetic; potent IAP inhibitor

Chemical Name: 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide

Purity: ≥97%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

AZD 5582 dihydrochloride is a dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice.

Technical Data

M.Wt:
1088.21
Formula:
C58H78N8O8.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1883545-51-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd

Product Datasheets

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Citations for AZD 5582 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for AZD 5582 dihydrochloride include:

3 Citations: Showing 1 - 3

  1. A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency.
    Authors: Patrick J Et al.
    PLoS Pathog  2023;19:e1011101
  2. CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux.
    Authors: Ying Et al.
    Autophagy  2022;18:726-744
  3. ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect.
    Authors: Zinecker Et al.
    Oncotarget  2017;8:106764

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