BAM (8-22)

Tocris Bioscience | Catalog # 1763

Potent MRGPRX1 agonist
Tocris Bioscience

Key Product Details

Description

Potent MRGPRX1 agonist
View all Mas-Related G Protein Coupled Receptor Agonists »

Product Description

BAM (8-22) is an endogenous peptide fragment that is a potent agonist for MRGPRX1 (EC50 values are 8 - 150 nM). It was first isolated from bovine adrenal medulla. Unlike BAM 22P (Cat. No. 1650), BAM (8-22) does not contain the met-enkephalin motif therefore displays no affinity for opioid receptors. BAM (8-22) augments scratching behavior in a cholestatic pruritus mice model. BAM (8-22) attenuates bone cancer pain in mice.

Product Specifications for BAM (8-22)

Molecular Weight

1971.22

Formula

C91H127N25O23S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

412961-36-5

PubChem ID

16158367

InChI Key

GOEYECACIBFJGZ-NPAGUKBMSA-N

SMILES

[H]N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Product Documents for BAM (8-22)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for BAM (8-22)

For research use only

Customer Reviews for BAM (8-22) (1)

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  • Excellent In vivo and ex vivo activity with miminal lot variation
    Name: Jeff Guo
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: Dorsal Root Ganglia
    Verified Customer | Posted 11/30/2023
    Demonstrates excellent bio-activity and virtually free of batch/lot-effects in both in vivo mouse behavioral assays (low mM concentrations) and ex vivo calcium imaging assays (low μM concentrations). Highly recommended to minimize variation, for critical assays, and for generating publication quality data. Attached image shows representative calcium response of ex vivo dorsal root ganglia in response to bath applied 10 μM BAM 8-22. Image is composite of GCaMP3 fluorescence intensity over 180 seconds, after baseline subtraction, with contract and brightness adjustments to improve image clarity.
    BAM (8-22) 1763

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