Bay 36-7620
Chemical Name: (3aS,6aS)-Hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-1H-cyclopenta[c]furan-1-one
Purity: ≥98%
Biological Activity
Bay 36-7620 is a selective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity. Impairs classical conditioning and associated synaptic plasticity in hippocampal neurons. Exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Agonist-dependent signaling by group I metabotropic glutamate receptors is regulated by association with lipid domains.
Kumari, Ranju, Castillo, Catherin, Francesconi, Anna
J Biol Chem, 2013;288(44):32004-19. -
Actinin-4 Governs Dendritic Spine Dynamics and Promotes Their Remodeling by Metabotropic Glutamate Receptors.
Kalinowska M, Chavez A, Lutzu S, Castillo P, Bukauskas F, Francesconi A
J Biol Chem, 2015;290(26):15909-20. -
BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity.
Carroll et al.
Mol.Pharmacol., 2001;59:965 -
Neuroprotective and behavioural effects of the selective metabotropic glutamate mGlu1 receptor antagonist BAY 36-7620.
De Vry et al.
Eur.J.Pharmacol., 2001;428:203 -
Involvement of the mGluR1 receptor in hippocampal synaptic plasticity and associative learning in behaving mice.
Gil-Sanz et al.
Cereb.Cortex, 2007;18:1653
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Citations for Bay 36-7620
The citations listed below are publications that use Tocris products. Selected citations for Bay 36-7620 include:
9 Citations: Showing 1 - 9
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Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer.
Authors: Sexton Et al.
Sci Rep 2018;8:16008
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R.zole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells.
Authors: Dolfi Et al.
Oncotarget 2017;8:44639
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Mechanisms of tau and Aβ-induced excitotoxicity.
Authors: Pallo Et al.
Brain Res 2016;1634:119
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Disruption of GRM1-mediated signalling using R.zole results in DNA damage in melanoma cells.
Authors: Wall Et al.
Pigment Cell Melanoma Res 2014;27:263
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Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation.
Authors: Veettil Et al.
PLoS Pathog 2014;10:e1004389
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Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer.
Authors: Speyer Et al.
Breast Cancer Res Treat 2012;132:565
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Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear.
Authors: Tronson Et al.
Autophagy 2010;68:1007
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The glutamate release inhibitor R.zole decreases migration, invasion, and proliferation of melanoma cells.
Authors: Le Et al.
J Invest Dermatol 2010;130:2240
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mGluR(1) Receptors Contribute to Non-Purinergic Slow Excitatory Transmission to Submucosal VIP Neurons of Guinea-Pig Ileum.
Authors: Foong
Front Neurosci 2009;3:46
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